Fig. 1: Differences in the cumulative effect of genetic polymorphisms on the expression of SARS-CoV-2 entry mediators ACE2 and TMPRSS2 between populations.
From: Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations
Upper left Genetic expression score of ACE2 in female individuals. ANOVA P < 0.0001. Adjusted P values using Tukey’s multiple comparisons test: African vs. European, P = 0.47; African vs. Admixed American, P = 0.043; African vs. East Asian, P < 0.0001; African vs. South Asian, P < 0.0001; European vs. Admixed American, P = 0.71; European vs. East Asian, P = 0.0175; European vs. South Asian, P < 0.0001; Admixed American vs. East Asian, P = 0.56; Admixed American vs. South Asian, P < 0.0001; East Asian vs. South Asian, P = 0.0017. Upper right Genetic expression score of ACE2 in male individuals. ANOVA P < 0.0001. Adjusted P values using Tukey’s multiple comparisons test: African vs. European, P = 0.14; African vs. Admixed American, P = 0.17; African vs. East Asian, P < 0.0001; African vs. South Asian, P < 0.0001; European vs. Admixed American, P = 1; European vs. East Asian, P < 0.0001; European vs. South Asian, P < 0.0001; Admixed American vs. East Asian, P = 0.0004; Admixed American vs. South Asian, P = 0.0009; East Asian vs. South Asian, P = 1. Lower left Genetic expression score of TMPRSS2 in female individuals. ANOVA P < 0.0001. Adjusted P values using Tukey’s multiple comparisons test: African vs. European, P < 0.0001; African vs. Admixed American, P < 0.0001; African vs. East Asian, P < 0.0001; African vs. South Asian, P < 0.0001; European vs. Admixed American, P = 0.97; European vs. East Asian, P = 0.95; European vs. South Asian, P = 0.93; Admixed American vs. East Asian, P = 1; Admixed American vs. South Asian, P = 0.66; East Asian vs. South Asian, P = 0.55. Lower right Genetic expression score of TMPRSS2 in male individuals. ANOVA P < 0.0001. Adjusted P values using Tukey’s multiple comparisons test: African vs. European, P < 0.0001; African vs. Admixed American, P < 0.0001; African vs. East Asian, P < 0.0001; African vs. South Asian, P < 0.0001; European vs. Admixed American, P = 0.084; European vs. East Asian, P = 0.03; European vs. South Asian, P = 1; Admixed American vs. East Asian, P = 1; Admixed American vs. South Asian, P = 0.053; East Asian vs. South Asian, P = 0.015.
