Table 2 Comparison of key features in different databases that profile IG germline alleles.
IMGT | VBASE2 | IgPdb | pmIG | |
|---|---|---|---|---|
Ethnic origin | None | None | None | Available |
Allelic frequency per ethnic group/population | None | None | None | Available |
Cell-source for alleles | Unclear | Unclear | Unclear | Available |
All germline genes from single individuals | No | No | No | Yes (from all 2504 individuals) |
Completeness of IGHV alleles | 138 Complete and 98 Partial | V region only | V region only | All complete (including leader) |
Completeness of IGKV alleles | 71 Complete and 9 Partial | V region only | V region only | All complete (including leader) |
Completeness of IGLV alleles | 39 Complete and 35 Partial | V region only | V region only | All complete (including leader) |
Presence of IGHD and IGHJ genes | Available | None | A few | Available |
Presence of IGKJ genes | Available | None | A few | Available |
Presence of IGLJ genes | Available | None | A few | Available |
Presence of IGHC genes | Available | None | None | Available |
Presence of IGKC gene | Available | None | None | Available |
Presence of IGLC genes | Available | None | None | Available |
RSS | Available | None | None | Available |
Completeness in terms of alternate duplicated genes | Complete | No (Not all genes present) | No (Not all genes present) | Complete as per availability from GRCh37 |
Strategy for exclusion of SHM | Not reported | Not reported | Not reported | Explicitly reported with avoidance of SHM by strict rules |
Confidence levels | NONE | Class-1, 2, 3 | None | Double layer of confidence levels (Confidence levels with information on group genes and OI genes) |
