Fig. 1: TR loci organization and gene rearrangements during human lymphoid differentiation.
From: pmTR database: population matched (pm) germline allelic variants of T-cell receptor (TR) loci
A Schematic overview of the four TR loci: TRB, TRA, TRD and TRG. Genomic position of the loci is indicated in brackets. In TR loci each rectangle depicts one of the variable (V), diversity (D), joining (J) and constant (C) genes. The number of known functional genes, as listed in the IMGT, is indicated underneath each scheme. B Overview of TR gene rearrangements during human precursor T-cell differentiation in the thymus. HSC hematopoietic stem cell, DN double negative thymocyte, DP double positive thymocyte, ISP immature single positive thymocyte, SP single positive thymocyte. The figure was adapted from Langerak et al. [38].
