Fig. 2: RNA-seq of IgE-binding monocytes reveals DEGs in allergic horses during both Remission and Clinical Phases.
From: IgE-binding monocytes upregulate the coagulation cascade in allergic horses
Normalized read counts were compared between healthy (n = 5) and allergic (n = 7) horses during the “Remission Phase” in January and the “Clinical Phase” in August. Volcano plots describe differentially expressed genes (DEGs) in allergic horses compared to healthy horses. Genes in the upper right and upper left regions are significantly up- (red) or downregulated (blue) in allergic horses, respectively. A DEGs during the “Remission Phase”. B DEGs during the “Clinical Phase”. Significant DEGs (p < 0.05) that were upregulated by > 1.5-fold change (red, positive log2(FC) values) or downregulated by > 1.5-fold change (blue, negative log2(FC) values) are labeled with corresponding gene names. Genes with +/− fold change (FC) values between 0.9 and 1.5 and p < 0.05 (green) are also labeled with gene name. Dotted lines have been added to aid visualization of DEGs. The horizontal dotted line shows the -log10 of the false discovery rate (FDR) threshold of 0.05 and values above this line are statistically significant. The vertical dotted lines show +/−1.5 FC in allergic compared to healthy horses.
