Fig. 1: Correlation of TIMP1 gene expression with improved survival, T-cell infiltration, and antigen presentation in melanoma. | Genes & Immunity

Fig. 1: Correlation of TIMP1 gene expression with improved survival, T-cell infiltration, and antigen presentation in melanoma.

From: TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity

Fig. 1

A Kaplan-Meier plots of overall survival (OS) based on TIMP1 (red and blue) and CD8A (green and black) gene expressions (cutoff determined by the median of gene expression within the cohort), demonstrating significant differences in the OS curves determined by TIMP1 and CD8A differential expression. B, left Spearman’s correlation screening of TIMP1 with CD8A gene expression in all cancer cohorts of the normalized GDC-TCGA-PANCAN dataset. The heatmap represents the significance of correlations based on a two-tailed test. B, right Quantitative Spearman’s correlation between TIMP1 and significant HLA-related genes (p < 0.05); in red, genes controlling peptide loading onto MHC-II and MHC-I molecules (****p < 0.0001, ***0.0001<p < 0.001, **0.001<p < 0.01 and *0.01<p < 0.05 are considered significant). C Force Atlas 2 Network study displaying genes as nodes and correlations as edges, with correlation strength indicated by edge distance, revealing TIMP1’s stronger relationships with HLA genes compared to HFE.

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