Fig. 2: Expansion of VH4 family and individual VH4 genes by PBs from pwRIS. | Genes & Immunity

Fig. 2: Expansion of VH4 family and individual VH4 genes by PBs from pwRIS.

From: Increased VH4+JH6+ antibody heavy chain use in plasmablasts from asymptomatic multiple sclerosis patients

Fig. 2: Expansion of VH4 family and individual VH4 genes by PBs from pwRIS.The alternative text for this image may have been generated using AI.

Variable heavy chain family usage for families 1–7 was calculated for each subject of HC (n = 20), vs pwRIS (n = 31), vs pwCIS (n = 16) (A). The white bars represent HC, the middle light gray bars represent RIS, and the dark gray bars represent CIS. The ANOVA, p-value for VH4 use in (A) was p = 0.0006. VH4 family use of the RIS and CIS groups per subject are shown in (B). VH4 family use of the HC (n = 20) and MS (n = 36) groups per subject are shown in (C). Individual VH4 gene frequencies of the RIS and CIS groups are shown in (D). Individual VH4 gene frequencies of VH4-34, VH4-39, and VH4-59 are shown in (E–G), respectively, for the RIS and CIS groups. **p = 0.005; *p < 0.05.

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