Fig. 2: FANCM PV impairs DNA break repair in patients.
From: A homozygous FANCM frameshift pathogenic variant causes male infertility
a A representative cultured metaphase lymphocyte from patients after 300 nM MMC treatment. Chromosomal breaks are indicated by arrowheads. b Quantification of chromosomal breaks in lymphocytes from patients (VI:2 and VI:3) and their father (III:1) after MMC treatment range from 0 nM to 300 nM. At least 40 cells were scored for each group. Data are represented as mean ± SEM from at least two independent experiments. *p < 0.05, ***p < 0.001; one-way analysis of variance (ANOVA) test
