Fig. 1: Mutations in NOTCH3  EGFr domains 1–6 are associated with an earlier age of onset of stroke and lower life expectancy than PV in EGFr domains 7–34. | Genetics in Medicine

Fig. 1: Mutations in NOTCH3  EGFr domains 1–6 are associated with an earlier age of onset of stroke and lower life expectancy than PV in EGFr domains 7–34.

From: The effect of NOTCH3 pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1–6 pathogenic variant are associated with a more severe phenotype and lower survival compared with EGFr 7–34 pathogenic variant

Fig. 1

a, b, Kaplan–Meier plots showing the differences in (a) age of onset of first stroke and (b) survival stratified according to mutation position for patients with epidermal growth factor-like repeat (EGFr) domain 1–6 PV versus those with EGFr domain 7–34 PV

Back to article page