Table 2 Characteristics of patients in the European CADASIL sample

From: The effect of NOTCH3 pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1–6 pathogenic variant are associated with a more severe phenotype and lower survival compared with EGFr 7–34 pathogenic variant

 

EGFr 1–6

EGFr 7–34

P value

n

290

122

 

Mean age (years (95% CI))

48.8 (47.5–50.1)

57.3 (55.3–59.4)

<0.001

Male/female (% male)

130/160 (44.8)

55/67 (45.1)

0.962

Smoking, yes/no (%)

84/206 (29.0)

18/104 (14.8)

0.002

Pack years

5.7 (4.2–7.2)

13.0 (−0.4–26.3)

0.11

Hypercholesterolaemia, yes/no (%)

129/161 (44.5)

63/59 (51.6)

0.184

Hypertension, yes/no (%)

45/245 (15.5)

38/84 (31.1)

<0.001

Diabetes, yes/no (%)

6/284 (2.1)

3/119 (2.5)

0.728

  1. EGFr Epidermal growth factor-like repeat
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