Fig. 3
From: IQSEC2-related encephalopathy in males and females: a comparative study including 37 novel patients
Comparison of ID severity, seizure onset, and pharmacoresistance in males and females with IQSEC2 variants. (a) Violin plots showing the distribution of intellectual disability (ID) degree in males (blue) and females (pink). The distribution of males is clearly shifted to the most severe end of the spectrum while cognitive impairment is on average less severe, but also more variable, in females. (b) Violin plots comparing the age at seizure onset in months (y-axis) in males (blue) and females (pink), illustrating that epilepsy tends to appear later in females. (c) Violin plots comparing the resistance to antiepileptic treatments (AETs) (y-axis) in males (blue) and females (pink), showing that epilepsy in males are on average more pharmacoresistant. (d) Absence of clear correlation between the degree of comparing the (y-axis) and age at seizure onset (x-axis). Blue circles: males; pink circles: females; mod: moderate; sev: severe; pro: profound. The numbers above indicate the patient ID number
