Fig. 3

Dual energy X-ray absorptiometry (DXA)-estimated changes in tissue volume during study period. a Change in absolute volumes in ml at affected and unaffected sites at the beginning of the run-in period (week 0), after the 26-week run-in period (week 26), and after the 26-week sirolimus treatment period (week 52). Note major differences in the magnitude and variability of volume measurements between affected and unaffected sites. b Change in percent tissue volume at affected and unaffected sites during the run-in period at week 26 and during the sirolimus treatment phase at week 52. Individual values plotted, bars denote mean values and error bars standard deviation. c Post hoc subanalysis of progressive growth during the run-in period. Linear regression analysis of % volume change during run-in period, i.e., whether or not subjects had progressive overgrowth versus difference in % volume change between the run-in and treatment phase at affected sites. The result was significant implying the largest effect sizes were obtained in subjects with progressive overgrowth during the run-in period.