Table 2 Number of carriers detected by ethnicity-based screening or ECS stratified by self-reported ethnicity
Ethnicity | Total | Carriers (%) | Panel comparison (p value) | ||||
|---|---|---|---|---|---|---|---|
(self-reported) | N (%) | Ethnicity-based | ACOG-based | ECS | Ethnicity vs. ACOG based | Ethnicity-based vs. ECS | ACOG-based vs. ECS |
Mixed or Other Caucasian | 1089 | 65 | 180 | 365 | 6.3 × 10-15 | < 2.2 × 10-16 | < 2.2 × 10-16 |
(25.7) | (6.0) | (16.5) | (33.5) | ||||
Southern European | 510 | 42 | 83 | 160 | 9.0 × 10-5 | < 2.2 × 10-16 | 1.5 × 10-8 |
(12.1) | (8.2) | (16.3) | (31.4) | ||||
Hispanic | 480 | 36 | 52 | 97 | 0.074 | 1.2 × 10-8 | 6.0 × 10-5 |
(11.3) | (7.5) | (10.8) | (20.2) | ||||
Northern European | 393 | 30 | 61 | 116 | 0.00055 | 3.1 × 10-15 | 2.6 × 10-6 |
(9.3) | (7.6) | (15.5) | (29.5) | ||||
Unknown/Not Reported | 383 | 22 | 70 | 133 | 9.6 × 10-8 | < 2.2 × 10-16 | 2.5 × 10-7 |
(9.1) | (5.5) | (18.1) | (34.6) | ||||
African or African American | 377 | 55 | 63 | 80 | 0.42 | 0.018 | 0.11 |
(8.9) | (14.6) | (16.7) | (21.2) | ||||
Ashkenazi Jewish | 359 | 71 | 102 | 197 | 0.0068 | < 2.2 × 10-16 | 6.4 × 10-13 |
(8.5) | (19.8) | (28.4) | (54.9) | ||||
South Asian | 277 | 18 | 23 | 44 | 0.42 | 0.00046 | 0.0062 |
(6.5) | (6.5) | (8.3) | (15.9) | ||||
East Asian | 206 | 5 | 6 | 13 | 0.76 | 0.054 | 0.10 |
(4.9) | (2.4) | (2.9) | (6.3) | ||||
Middle Eastern | 75 | 4 | 7 | 23 | 0.53 | 7.6 × 10-5 | 0.0011 |
(1.8) | (5.3) | (9.3) | (30.7) | ||||
Southeast Asian | 71 | 10 | 10 | 11 | 1 | 0.81 | 0.81 |
(1.7) | (14.1) | (14.1) | (15.5) | ||||
French Canadian or Cajun | 5 | 0 | 1 | 2 | – | – | – |
(0.12) | (0) | (20.0) | (40.0) | ||||
Pacific Islander | 4 | 1 | 1 | 1 | – | – | – |
(0.095) | (25.0) | (25.0) | (25.0) | ||||
Native American | 3 | 0 | 0 | 1 | – | – | – |
(0.071) | (0) | (0) | (33.3) | ||||
Total | 4232 | 359 | 659 | 1243 | < 2.2 × 10-16 | < 2.2 × 10-16 | < 2.2 × 10-16 |
(100) | (8.5) | (15.6) | (29.4) | ||||
