Fig. 2 | Genetics in Medicine

Fig. 2

From: eKLIPse: a sensitive tool for the detection and quantification of mitochondrial DNA deletions from next-generation sequencing data

Fig. 2

Graphical representation of eKLIPse. The outer circle depicts the mitochondrial genome with annotated transfer RNAs (tRNAs) (orange), ribosomal RNAs (rRNAs) (purple), protein-coding genes (green), and noncoding regions (black). The gray gradient allows estimating the cumulative percentage of deletions, which are represented by the black line for each mitochondrial DNA (mtDNA) position. For each sample, the depth of coverage at each base is shown as a blue area, whereas the median coverage of all samples is represented as the royal blue line. Soft-clipping peaks are represented within the inner circle as black bars, whose size is proportional to the number of soft-clipped sequences. Reciprocal bidirectional BLASTs are represented by red arcs with intensities (from light to dark red) proportional to the level of mtDNA deletions. The plot was produced using Circos software, version 0.6 (http://circos.ca).

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