Table 1 Barriers and facilitators to genomic testing implementation based on the CFIR framework inner setting constructs25

From: Qualitative study of system-level factors related to genomic implementation

CFIR framework: inner setting

Applied construct

CFIR construct

Implementation application for research and clinical practice

Barriers

Incorporating genomics into electronic health records

Available Resources Stakeholder Engagement

• Lack of integration of decision support tools or testing results into electronic health records (EHR)

• Current technology lacks appropriate computer logic for interpretation of genomic testing

• Required IT collaboration for integration

Reluctance to do genomics research

Culture Stakeholder Engagement

• Unease in accepting research without guarantee for improvement of patient health

• Physician preference for known technology or procedures

• Not all patients have comfort with genomic testing and limited patient buy-in

Reimbursement

Infrastructure Changes

• Lack of funding for testing outside of research setting

• Limited avenues for reimbursement for genomic testing in current health-care climate

Facilitators

Investigator and clinician communication

Networks & Communication Goals & Feedback

• Use of various platforms to share information about research projects: meetings, conferences, and grand rounds

• Conference calls for all sites to introduce study, standardize procedures, and problem solve

• Solicitation of feedback in detailing best practices for project implementation

• Communication between clinicians about genomic testing and integrating genomic testing into practice

Clinician champions as facilitators of genomic implementation

Stakeholder Engagement Leadership Engagement

• Establishment of physician leadership on a departmental level to assist with recruitment and buy-in

• Use of early adopters to encourage participation from other clinicians

• Recommendation to use testing and support tools between clinicians

Leadership engagement

Leadership Engagement Available Resources

• Hospital administration or leadership support for research and required resources

• Access to funding or administrative assets for research required changes to technology, labs, or clinic settings

• Buy-in from C-level to increase project priority and reduce administrative concerns

  1. CFIR Consolidated Framework for Implementation Research, IT information technology.