Fig. 2
From: Insights into genetics, human biology and disease gleaned from family based genomic studies
Cumulative Centers for Mendelian Genomics (CMG) disease gene discovery. The number of novel gene–phenotype discoveries as reported by all four centers is graphed by progress reporting period (blue bars) and cumulatively (red bars). Biannual phenotypic expansion discoveries involving previously known disease genes (green line) and biannual known disease gene discoveries (yellow line) are also graphed. The yellow arrow indicates the pace of novel gene–phenotype discovery, and demonstrates a pace of 263 novel gene–phenotype discoveries per year, or 1 novel gene–phenotype discovery for every 28 exome sequences (ES) performed.
