Fig. 3
From: Insights into genetics, human biology and disease gleaned from family based genomic studies
Matchmaking tools developed through the Centers for Mendelian Genomics (CMGs). (a) The Matchmaker Exchange (MME) facilitates communication among multiple databases of human genomic and phenotypic data, each unique in focus and design. Each database functions as a node within the MME. (b) Total number of entries in each MME node, as well as total number of entries per node shared within the MME, are indicated. Also listed is the total number of unique genes per node. Note that a given unique gene may be present in more than one node. (c) Cumulative GeneMatcher statistics demonstrate 26,614 submissions of 10,341 genes through 1 November 2018. This has resulted in 5195 matched genes. GeneMatcher submitters in 77 countries today, demonstrating worldwide democratization of disease gene discovery. (d) MyGene2 is a database through which patients and families can directly share their genomic data. Matchbox is an open-source tool through which institutions or groups with genomic data can connect to the MME.
