Fig. 1

Proposed diagnostic schema of endometrial cancer screening for Lynch syndrome. Consent should be sought from the patient before germline testing. ^#We recognize the possibility of using a two protein screen using PMS2 and MSH6 initially, however the evidence base is not definitive. *If only microsatellite testing used without immunohistochemistry then all those found to be MSI-H should either be further triaged with methylation testing or undergo direct germline analysis. IHC immunohistochemistry, MSI-H microsatellite instability high, MSI-L microsatellite instability low, MMR mismatch repair, MSS microsatellite stable.