Table 1 Overview of clinical trials^{20,21,22,23,24,25,26,27,28,29,30,31,32,33,34}

	CYP2D6-opioids			CYP2C19-PPI		CYP2D6/CYP2C19-SSRIs
	OneFlorida Primary Care	UF Health Primary Care	UF Health & Moffitt Specialty Clinics	UF Health Specialty Clinics	Nemours Children’s Health Specialty Clinics	UF Health Specialty Clinics
Number of participating clinics	2	7	2	1	3	1
Eligibility criteria^a	Adults with chronic, noncancer pain		Adults with cancerassociated pain	Adults with GERD	Children with GERD	Children with depression, anxiety, or OCD
Total participants	104	371	86	123	60	49
Enrollment period	7/2015–4/2016	5/2015–6/2017	4/2016–4/2018	1/2017–7/2017	3/2017–8/2017	9/2016–1/2017
Study duration	12 weeks		8 weeks	12 weeks		12 weeks
					SN-5	Side effects
Questionnaire(s) or tool used	Pain-CHOIR^b		BPI-SF MDASI	GOS RDQ	SafetyQ PedsQL GASP-Q	CDI SCARED OCI-R
Total questions	70^b		55	29	105	114
Weeks administered	0, 12		0,2,4,6,8	0,12	0-12c	0, 1, 2, 4, 8, 12

BPI-SF Brief Pain Inventory–Short Form, CDI Children’s Depression Inventory, CHOIR Collaborative Health Outcomes Information Registry, GASP-Q GERD Assessment of Symptoms in Pediatrics Questionnaire, GERD gastroesophageal reflux disease, GOS Global Overall Symptom Scale, MDASI M.D. Anderson Symptom Inventory, OCD obsessive compulsive disorder, OCI-R Obsessive Compulsive Inventory, PedsQL Pediatric Quality of Life Inventory, PPI proton pump inhibitor, RDQ Reflux Disease Questionnaire, SafetyQ Safety Questionnaire, SCARED Screen for Child Anxiety Related Emotional Disorders, SN-5 Pediatric Sinonasal Symptom Survey, SSRI selective serotonin reuptake inhibitor.
^aDetailed eligibility criteria are available elsewhere (clinicaltrials.gov: NCT02335307, NCT02664350, NCT02930824, and NCT02855580.^20,21,^–²²
^bThe pain-CHOIR tool used adaptive testing; we report the approximate average number answered.
^cExcept SN-5, which was administered at weeks 0, 4, 8, and 12.

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