Fig. 3 | Genetics in Medicine

Fig. 3

From: Intrathecal enzyme replacement for Hurler syndrome: biomarker association with neurocognitive outcomes

Fig. 3

Correspondence of biochemical change with IQ outcome. Percent change in IQ from baseline (i.e., pretreatment) to 2-year posttransplant anniversary is plotted against percent reduction in nonreducing end (NRE) I0S6 from time point 1 to 4, i.e., pretreatment through final intrathecal recombinant iduronidase infusion occurring 6 months posttransplant (N = 15). A significant association was found, such that percent decrease in I0S6 was significantly associated with more favorable change in IQ (p = 0.0035). CI confidence interval.

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