Table 1 Comparison of CPADs and CPGs

From: Improving recommendations for genomic medicine: building an evolutionary process from clinical practice advisory documents to guidelines

Key feature

CPADs

CPGs

State of field and testing technology

Early in assessment of the field and testing technology

Later in assessment of the field and testing technology

State of the evidence

Insufficient evidence to evaluate benefits and harms of testing

Sufficient evidence to evaluate benefits and harms of testing

Product(s)

(1) Advice for clinicians based largely on expert judgment about the potential benefits and harms of testing, the uncertainties in current evidence, and the trade-offs for different approaches

(2) Recommendations for research to improve clinical test use

Recommendations for clinical practice based on evaluation of the evidence, with strength of recommendations determined by quality of evidence

Updating

Annual review of relevant evidence with revision of CPAD or decision to proceed to CPG

Appropriate plan for updating, as determined after CPG development

  1. CPAD clinical practice advisory document, CPG clinical practice guideline.