Table 2 Scoring system used to assess the strength of the criteria for reportability

From: Considerations for clinical curation, classification, and reporting of low-penetrance and low effect size variants associated with disease risk

 

0

1

2

3

Effect size

OR = 1

OR 1–2

OR 2–4

OR > 4

Effectiveness of intervention

Controversial or unknown effectiveness

Minimally effective

Moderately effective

Highly effective

Severity

Minimal or no morbidity

Modest morbidity

Possibility of death or major morbidity

Reasonable possibility of sudden death

Disease prevalence

Unknown

Rare (1:2000)

Intermediate (1:100–1:2000)

Common >1:100

Risk of intervention

High risk, poorly acceptable or intensive interventions OR no known intervention

Moderate risk, moderately acceptable or intensive interventions

Greater risk, less acceptable and substantial interventions

Low risk, or medically acceptable and low-intensity interventions

  1. OR odds ratio.