Table 4 Predictors of multimorbidity in adults with 22q11.2DS

From: A genetic model for multimorbidity in young adults

Logistic regression analysis

Predictor

Total sample N = 264

Multimorbidity N = 75

No multimorbidity N = 189

OR

Wald 95% CI

P

Median

(Q1, 3)

Median

(Q1, 3)

Median

(Q1, 3)

   

Age (years)

27.8

(21.7, 39.5)

38.6

(30.8, 50.2)

25.5

(20.8, 33.1)

1.07

1.04–1.10

<0.0001

 

N

%

N

%

N

%

   

Psychotic illness

109

41.3

55

73.3

54

28.6

5.48

2.73–11.00

<0.0001

ID

23

8.7

8

10.7

15

7.9

1.70

0.55–5.25

0.35

CHD

101

38.3

16

21.3

85

45.0

0.79

0.37–1.70

0.55

Female sex

140

53.0

41

54.7

99

52.4

1.10

0.58–2.10

0.76

  1. Multimorbidity = 5 or more medications, no multimorbidity = less than 5 medications. Age is age at medication recording. Q1,3 = lower quantile, upper quantile. See “Materials and Methods” for details. Overall the model was significant (χ2[df 5] = 76.3, p < 0.0001).  Signifiant P values are bolded. 
  2. CHD congenital heart disease (moderate or complex),32 CI confidence interval, ID   intellectual disability (moderate or severe),33 OR odds ratio.
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