Table 3 Summary of all association studies between CPMs and outcomes

From: Outcomes in pregnancies with a confined placental mosaicism and implications for prenatal screening using cell-free DNA

Outcome

CPM (RATs excluding T16) N = 94

CPM (tetraploidy only) N = 18

CPM (T16 only) N = 12

Controls N = 468

Significant associations

Binary outcome variables (X2)

# Abnormal outcome/total (%)

# Abnormal outcome/total (%)

 

P valuea

 Birthweight percentile <3rd

3/87 (3.4%)

0/17

3/11 (27.3%)

13/401 (3.2%)

T16 only

P 1.0

P 0.672

P 0.007

 FGR

7/92 (7.6%)

2/17 (11.8%)

2/12 (16.7%)

10/428 (2.3%)

RATs (excluding t16) T16 only

P 0.018

P 0.072

P 0.039

 NICU admission (excluding FGR)

5/84 (6%)

1/18 (5.6%)

1/10 (10%)

8/420 (1.9%)

RATs (excluding T16)

P 0.049

P 0.317

P 0.192

 HD

6/92 (6.5%)

1/18 (5.6%)

1/12 (8.3%)

20/428 (4.7%)

None

P 0.60

P 1.0

P 1.0

 Spontaneous PTD

4/81 (4.9%)

0/16 (0%)

2/9 (22.2%)

11/403 (2.7%)

T16 only

P 0.48

P 1.0

P 0.029

Quantitative outcome variables (Mann–Whitney rank-sum test)

N (median, IQR, 25th–75th percentile)

N (median, IQR, 25th–75th percentile)

 

P valuea

 Birthweight percentile

N = 87 (49, 52, 26–78)

N = 17 (44, 37, 25–63)

N = 11 (35, 89, 2–91)

N = 401 (55, 50, 31–81)

None

P 0.257

P 0.186

P 0.181

 Apgar score at 5 minutes

N = 87 (10, 1, 9–10)

N = 17 (9, 1, 9–10)

N = 11 (9, 0, 9–9)

N = 408 (10, 1, 9–10)

T16 only

P 0.477

P 0.120

P 0.006

  1. aP values compare the CPM group versus controls.
  2. CPM confined placental mosaicism, FGR fetal growth restriction, HD hypertensive disorders of pregnancy, IQR interquartile range, NICU neonatal intensive care unit, PTD preterm birth, T16 trisomy 16.
  3. Statistically significant p-values are in bold underlined p < 0.05.
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