Table 1 CardioBoost outperforms existing genome-wide tools for the classification of holdout test variants.

Overall accuracy

63.3^a

28.4

17.4

81.2^a

30.5

37

Proportion of variants classified with high confidence

70.2^a

33.9

22

88.3^a

33.8

40.3

Accuracy of high-confidence classifications

90.2

83.8

79.2

91.9

90.4

91.9

Proportion of variants with indeterminate classification

29.8^a

66.1

78

11.7^a

66.2

59.7

 TPR

69.5^a

41.5

28

83.3^a

48.8

65.5

 PPV

86.3

81.7

76.7

90.9

91.1

91.7

 TNR

56^a

13

5

78.6^a

8.6

2.9

 NPV

96.6

92.9

100

93.2

85.7

100