Table 3 Costs by cohort.

From: Exome sequencing compared with standard genetic tests for critically ill infants with suspected genetic conditions

Cost category, mean (SD)a

All patients

ES cohort

No-ES cohort

p value

 

(n = 736)

(n = 368)

(n = 368)

 

Total cost of index admission

272,600 (401,499)

326,698 (449,888)

218,503 (338,488)

<0.001

Total cost of index year

338,179 (421,266)

409,591 (466,617)

266,768 (357,009)

<0.001

Total cost of index admission diagnostic pathway

11,632 (9429)

16,871 (9773)

6393 (5243)

<0.001

Total cost of index year diagnostic pathway

13,886 (10,398)

20,188 (10,034)

7584 (6018)

<0.001

Total cost of index admission genetic tests

6322 (6534)

10,227 (6817)

2417 (2905)

<0.001

Total cost of index year genetic tests

7239 (7266)

11,851 (7061)

2627 (3633)

<0.001

Cost (index admission diagnostic pathway) per diagnosis, [95% CI]b

60,869 [49,784–71,953]

24,763 [19,956–29,569]

  
  1. SD standard deviation, CI confidence interval, ES exome sequencing. aAll costs reported in 2017 USD. b95% CI constructed from 1000 bootstrap replicates.