Fig. 3: RNA analysis of BRCA2 variants. | Genetics in Medicine

Fig. 3: RNA analysis of BRCA2 variants.

From: Alternative mRNA splicing can attenuate the pathogenicity of presumed loss-of-function variants in BRCA2

Fig. 3Fig. 3

Splicing patterns of BRCA2 variants in or surrounding (a) Ex2–7, (b) Ex8–13, (c) Ex14–17, (d) Ex18–26. The location of exonic primers used for RT-PCR is indicated by arrows above the schematic representation of the analyzed cDNA region. Unique mRNA transcripts indicated in this figure by “other” are defined in Tables S1–S3. Asterisks denote nonsense variants. + transcript detected. FL full length, M marker (Smartladder 200 to 10000 bp from Eurogentec) WT wild type.

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