Fig. 3: Relationship between the yeast mutagenesis functional assays and in silico structural 3D modeling for each pol2 variant. | Genetics in Medicine

Fig. 3: Relationship between the yeast mutagenesis functional assays and in silico structural 3D modeling for each pol2 variant.

From: Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction

Fig. 3

The pol2 yeast variants are ranked on the x-axis from highest to lowest mutator strain with the human (h) analog substitutions in parentheses; pol2_AIA is the exonuclease-deficient variant (red), pol2_wt is the wild-type strain (purple). Error bars indicate the 95% confidence intervals.

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