Table 1 Sample characteristics.

From: COVID-19 outcomes and the human genome

Discovery Categories

Approach

Yield

Non-COVID-19 Example

A

Rare Phenotypic Outliers

“Undiagnosed disease” approach, including family-based analysis when possible

Rare monogenic associations may be found in as many as 25-30% of cases19,20

IRF7 deficiency6

B

Variants Associated with Specific Susceptibility

Cases and controls looking at risk for infection and complications of infection

Anticipate alleles with frequency 1% or above

aHBB

CFTR

CCR5

APOL1

C

Polygenic Risk Scores

Genome Wide Association Studies (GWAS) across varied populations and phenotypes

Identification and aggregation of COVID-19 associated variants genome-wide

Inflammatory bowel disease8

  1. aspecific HBB, CFTR, CCR5, and APOL1 alleles influencing infectious disease susceptibility are detailed in Supplemental Table 1.
Back to article page