Table 3 Associations of the best performing PRS in the prospective cohort of BRCA1 and BRCA2 carriers.

From: Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Outcome

 

PRS

Number of women at risk

Incident cancers

HR (95% CI)

P

Breast cancer

BRCA1 carriers

ER-

2088

297

1.28 (1.14–1.44)

4.44×10−5

BRCA2 carriers

BC

1757

215

1.36 (1.17–1.57)

4.26×10−5

Ovarian cancer

BRCA1 carriers

HGS

3152

108

1.28 (1.06–1.55)

1.08×10−2

BRCA2 carriers

HGS

2495

56

1.45 (1.13–1.86)

3.29×10−3

  1. Number of women at risk is the number of pathogenic variant carriers unaffected at baseline. Incident cancers is the number of women who developed breast/ovarian cancer during the follow-up period.
  2. BC breast cancer, CI confidence interval, ER- estrogen receptor negative, HGS high-grade serous, HR hazard ratio, PRS polygenic risk score.
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