Fig. 1: Elevated IGFBP7 plasma levels decrease under growth hormone therapy (GHT) in Prader–Willi syndrome (PWS) patients.
From: SNORD116 and growth hormone therapy impact IGFBP7 in Prader–Willi syndrome
(a) IGF1 (n = 21) and (b) IGFBP3 (n = 20) values in plasma of PWS patients at day 0 (D0) and after one year (M12) of GHT in 21 PWS patients. (c) IGFBP7 values in the plasma of PWS (n = 13) at D0 and M12 of GHT, and in age-matched controls (n = 18). The immunogen of antibodies used for enzyme-linked immunosorbent assay (ELISA) corresponded to the IGFBP7 sequence (ser28-thr264). Data are represented as mean ± SEM. (d) Pearson correlation between IGFBP7 (ng/ml) decreased and IGF1 (SDS) increased within one year of GHT (M12-D0 values) (n = 13). Pearson product-moment correlation coefficients (r) were used to assess the relationship between variables for PWS patients. ***P < 0.001, ns nonsignificant.
