Fig. 3: Clinical manifestations, age of onset, and survival analyses. | Genetics in Medicine

Fig. 3: Clinical manifestations, age of onset, and survival analyses.

From: Quantitative analysis of the natural history of prolidase deficiency: description of 17 families and systematic review of published cases

Fig. 3: Clinical manifestations, age of onset, and survival analyses.

(a,b) Main clinical manifestations reported at onset (a) and overall (b). (c) Linear regression model, including the observed slope (solid line) and the theoretical slope (dashed line) of diagnostic delay. (d–g) Overall survival (d), symptom-free survival (e), and ulcer-free survival for the entire cohort (f) and for missense and loss-of-function (LoF) variants (g).

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