Fig. 2: Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) on (pro)collagen extracted from patient skin fibroblasts. | Genetics in Medicine

Fig. 2: Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) on (pro)collagen extracted from patient skin fibroblasts.

From: Caffey disease is associated with distinct arginine to cysteine substitutions in the proα1(I) chain of type I procollagen

Fig. 2: Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) on (pro)collagen extracted from patient skin fibroblasts.The alternative text for this image may have been generated using AI.

Detection of disulfide-linked α1(I) dimers with SDS-PAGE from extracted (pro)collagen of dermal fibroblasts. In P1 (p.(Arg1014Cys)), an α1(I) dimer, indicated by an arrow, is detected in the intracellular and secreted fraction. In P26 (p.(Arg918Cys)), an α1(I) dimer is detected intracellularly, but not in the medium.

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