Fig. 4: Relationship of neoplasms and functional consequences of common MC1R missense variants. | Genetics in Medicine

Fig. 4: Relationship of neoplasms and functional consequences of common MC1R missense variants.

From: Large scale clinical exome sequencing uncovers the scope and severity of skin disorders associated with MC1R genetic variants

Fig. 4: Relationship of neoplasms and functional consequences of common MC1R missense variants.

(a) Plots of the odds ratio for various skin neoplasms versus EC50 for each common variant. The dotted line represents the EC50 for wild-type MC1R. (b) Plots of the odds ratio for various skin neoplasms versus maximum α-MSH induced cAMP for each common variant. Error bars represent 95% CI. The dotted line represents wild-type MC1R max cAMP (%L-858051). Symbols are color coded to match bars in Fig. 3.

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