Table 1 Simulation scenarios
From: Enhancing genetic disease control by selecting for lower host infectivity and susceptibility
Parameter | Basic parameter values | Alternative parameter values |
|---|---|---|
N, nsires, ndamspersire, noffspring per sire/dam | 10,000, 200, 50, 1 | – |
tgenerations of selection per replicate, nreplicates | 20, 50 | – |
Genetic variance for susceptibility in baseline population \(({\boldsymbol{\sigma }}_{{\boldsymbol{Ag}}}^2)\) | 0.5 | 0.2 |
Genetic variance for infectivity in baseline population \(({\boldsymbol{\sigma }}_{{\boldsymbol{Af}}}^2)\) | 0.5 | 0.2 |
Environmental variance for susceptibility \(({\boldsymbol{\sigma }}_{{\boldsymbol{Eg}}}^2)\) | 2 | 0.8 |
Environmental variance for infectivity \(({\boldsymbol{\sigma }}_{{\boldsymbol{Ef}}}^2)\) | 2 | 0.8 |
Average effective contact rate (β) | 0.02 | – |
Recovery rate (γ) | 0.017 | |
Selection accuracy for susceptibility (rg) | 0.7 | NA, 0.7 |
Selection accuracy for infectivity (rf) | NA | 0.7, 0.5, 0.4, 0.3, 0.2 |
Selected proportions of sires for susceptibility | 0.5 | NA, 0.5 |
Selected proportions of sires for infectivity | NA | 0.5, 0.8 |
Selected proportions of dams for susceptibility | 1 | – |
Selected proportions of dams for infectivity | 1 | – |
Contemporary group size | 100 | 20 |