Fig. 2 | Heredity

Fig. 2

From: A local score approach improves GWAS resolution and detects minor QTL: application to Medicago truncatula quantitative disease resistance to multiple Aphanomyces euteiches isolates

Fig. 2

Proportion of unique or multiple false-positive peaks across the simulated chromosome, detected with p-value-based tests (emmax method) and methods based on aggregation of p-values (Local Score, LHiSA, and LandScape). The empirical distributions of the maximum along the chromosome of −log10(p), Ak, H, and h, based on 1000 simulations of the null hypothesis of “no QTL effect,” were used to control the chromosome-wide FWER, by setting significance thresholds at the 80%, 90%, 95%, or 99% quantiles. Hence, the corresponding proportions of simulations showing at least one false positive was 20%, 10%, 5%, or 1%, respectively. Among these, we distinguished the proportion of simulations showing either unique or multiple false positive peaks across the simulated chromosome

Back to article page