Table 4 Top ten SNPs with the strongest effects from whole-genome prediction using Bayes-B method fitting all SNPs as random effects.

From: Integration of single nucleotide variants and whole-genome DNA methylation profiles for classification of rheumatoid arthritis cases from controls

SNP name

Chromosome: base pair

Alleles

Major allele

MAFa

Gene nameb

Distance from gene

Effect

rs11179382

12: 72820377

C/T

T

0.269

A lncRNA with ensemble code ID ENSG00000258235

91 Kb downstream

−0.26015

rs2077507

3: 11576994

A/G

A

0.287

Vestigial-like family member 4 (VGLL4)

Body

−0.25294

rs660895

6: 32609603

A/G

A

0.198

Major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1)

19 Kb upstream

−0.16400

rs2395175

6: 32437249

A/G

G

0.098

Major histocompatibility complex, class II, DR alpha (HLA-DRA)

2.6 Kb upstream

−0.10898

rs2395163

6: 32420032

C/T

T

0.153

Butyrophilin-like 2 (BTNL2)

13 Kb downstream

−0.09879

rs1004664

14: 24424005

G/T

T

0.376

KH and NYN domain containing (KHNYN)

Body

−0.08766

rs3763309

6: 32408196

A/C

C

0.150

Butyrophilin-like 2 (BTNL2)

Body

−0.07728

rs2395157

6: 32380368

A/G

A

0.208

A ncRNA LOC101929163 (uncharacterized)

Body

−0.06514

rs3817963

6: 32400310

A/G

A

0.257

Butyrophilin-like 2 (BTNL2)

Body

−0.05923

rs6910071

6: 32315077

A/G

A

0.105

Chromosome 6 open reading frame 10 (C6orf10)

Body

−0.05694

  1. aMAF minor allele frequency.
  2. bncRNA noncoding RNA, lncRNA long noncoding RNA.