Table 5 Top ten SNPs with the strongest effects from whole-genome/methylome prediction using Bayes-B and fitting all SNPs as random effects.

From: Integration of single nucleotide variants and whole-genome DNA methylation profiles for classification of rheumatoid arthritis cases from controls

SNP name

Chromosome: base pair

Alleles

Major allele

MAFa

Gene nameb

Distance from gene

Effect

rs1004664

14: 24424005

G/T

T

0.3756

KH and NYN domain containing (KHNYN)

Body

−0.00016

rs513203

12: 63545960

A/G

A

0.4643

A ncRNA class with ensemble code ID LOC105369797

Body

−0.00015

rs2077507

3: 11576994

A/G

A

0.2875

Vestigial-like family member 4 (VGLL4)

Body

−0.00014

rs11179382

12: 72820377

C/T

T

0.2686

A lncRNA with ensemble code ID ENSG00000258235

91.53 Kb downstream

−0.00014

rs2911738

8: 71674057

A/C

A

0.3361

A lincRNA with ensemble code ID ENSG00000254277

1.24 Kb upstream

−0.00013

rs2395175

6: 32437249

A/G

G

0.0982

Major histocompatibility complex, class II, DR alpha (HLA-DRA)

2.59 Kb upstream

−0.00013

rs8049226

16: 52423230

A/G

G

0.3672

An uncategorized gene with ensemble code ID ENSG00000279427

13.54 Kb upstream

−0.00013

rs1364616

8: 71654009

G/T

G

0.3321

A lincRNA with ensemble code ID ENSG00000254277

21.29 Kb upstream

−0.00012

rs6797550

3: 76747494

A/G

G

0.3281

Sapiens roundabout guidance receptor 2 (ROBO2)

Body

−0.00012

rs2595415

11: 6897324

C/T

C

0.2821

A ncRNA LOC107984019 (uncharacterized)

Body

−0.00012

  1. aMAF minor allele frequency.
  2. bncRNA noncoding RNA, lncRNA long noncoding RNA.