Table 6 Top ten methylation sites with the strongest effects from whole-methylome prediction using Bayes-B.

From: Integration of single nucleotide variants and whole-genome DNA methylation profiles for classification of rheumatoid arthritis cases from controls

Methylation sitea

Chromosome: base pair

Relation to island

Gene name

Relation to gene

Regulatory feature group

Effect

cg24147543

6: 32554481

S shelf

Major histocompatibility complex, class II, DR beta 1 (HLA-DRB1)

Body

NA

−0.00033

cg10132543

11: 68609520

N shore

Carnitine palmitoyltransferase 1A (CPT1A)

TSS200

NA

−0.00022

cg26572452*

8: 129115055

Open sea

Long intergenic nonprotein coding RNA 977 (LINC00977)

129.22 Kb upstream

Unclassified

−0.00021

cg04362887

14: 91285234

S shelf

Coiled-coil domain containing 88C (CCDC88C)

91.271 Kb downstream

NA

−0.00017

cg01695533

16: 86542905

Island

Forkhead box F1 (FOXF1)

TSS1500

Unclassified cell type specific

−0.00017

cg19741273

14: 101123263

S shore

Chromosome 14 open reading frame 70 (C14orf7)

TSS1500

NA

−0.00017

cg09717927

13: 112630399

N shore

ATP11A upstream neighbor (ATP11AUN)

112.26 Kb upstream

NA

−0.00017

cg05726118*

3: 41265374

Open sea

Catenin beta 1 (CTNNB1)

5’UTR

NA

−0.00017

cg18858739*

1: 167426278

S shore

CD247 molecule (CD247)

Body

Promoter associated cell type specific

−0.00017

cg12853199*

4: 13356876

Open sea

Member RAS oncogene family (RAB28)

13.361 Kb downstream

NA

−0.00016

  1. aMethylation sites with enhancer regulatory are shown by an ‘*’ on subscript.