Fig. 1: A simplified schematic showing how HIF-pathway-induced expression of erythropoietin (EPO) in the kidney stimulates expression of red blood cells and hemoglobin (Hb).
From: Adaptive introgression of the beta-globin cluster in two Andean waterfowl
The HBA and HBB genes are expressed in the bone marrow and other tissues during proerythroblast development (Gassmann and Muckenthaler 2015).
