Table 2 Allele and genotype frequencies for both linked and unlinked loci detected between three candidate genes (DRD4, SERT, and MC1R) in 180 female grey seals of Sable Island, Nova Scotia (Canada).
Locus | Major/minor allele | Location | MAF | HObs | HExp | HW P value | Genotype (frequency) | Protein coding | ||
|---|---|---|---|---|---|---|---|---|---|---|
DRD4 | ||||||||||
DRD4_1363a | C/T | Intron 3 | 0.116 | 0.17 | 0.21 | 0.168 | CC (0.8) | CT (0.17) | TT (0.032) | – |
DRD4_1496a | G/A | Intron 3 | 0.389 | 0.48 | 0.48 | 1.000 | GG (0.37) | AG (0.47) | AA (0.15) | – |
DRD4_1853a | C/T | Intron 3 | 0.331 | 0.37 | 0.44 | 0.204 | CC (0.48) | CT (0.37) | TT (0.14) | – |
SERT | ||||||||||
SERT_2946 | G/C | Intron 1 | 0.364 | 0.41 | 0.46 | 0.246 | GG (0.43) | GC (0.41) | CC (0.16) | – |
SERT_5987a | T/C | Intron 1 | 0.393 | 0.42 | 0.48 | 0.246 | TT (0.4) | TC (0.42) | CC (0.18) | – |
SERT_6056 | G/T | Intron 1 | 0.356 | 0.44 | 0.46 | 0.700 | GG (0.42) | GT (0.44) | TT (0.14) | – |
SERT_6147 | A/G | Intron 1 | 0.396 | 0.46 | 0.48 | 0.700 | AA (0.38) | AG (0.46) | GG (0.17) | – |
SERT_7235 | A/T | Intron 1 | 0.261 | – | – | – | AA (0.00) | AT (0.52) | TT (0.48) | – |
SERT_7535 | G/A | Intron 1 | 0.328 | 0.39 | 0.41 | 0.246 | GG (0.48) | GA (0.39) | AA (0.13) | – |
SERT_7540 | A/G | Intron 1 | 0.210 | 0.19 | 0.33 | 0.000 | GG (0.12) | GA (0.18) | AA (0.70) | – |
SERT_11432 | T/G | Intron 1 | 0.125 | 0.19 | 0.22 | 0.146 | TT (0.78) | TG (0.18) | GG (0.03) | – |
SERT_11673 | C/G | Exon 2 | 0.138 | 0.25 | 0.24 | 0.700 | CC (0.74) | CG (0.25) | GG (0.011) | Nonsynonymous |
SERT_11689 | C/T | Exon 2 | 0.478 | 0.92 | 0.50 | 0.000 | CC (0.06) | CT (0.92) | TT (0.016) | Nonsynonymous |
SERT_12472a | G/A | Intron 2 | 0.0819 | 0.13 | 0.15 | 0.204 | GG (0.85) | AG (0.13) | AA (0.017) | – |
SERT_15549 | G/A | Intron 3 | 0.409 | 0.43 | 0.48 | 0.270 | GG (0.38) | AG (0.43) | AA (0.19) | – |
SERT_15636a | G/A | Intron 3 | 0.308 | 0.53 | 0.43 | 0.003 | GG (0.43) | AG (0.53) | AA (0.04) | – |
SERT_16657 | C/G | Intron 4 | 0.286 | 0.41 | 0.41 | 1.000 | CC (0.51) | CG (0.41) | GG (0.082) | |
MC1R | ||||||||||
MC1R_126a | T/C | Exon 1 | 0.451 | 0.68 | 0.50 | 0.001 | CC (0.11) | CT (0.68) | TT (0.21) | Synonymous |
MC1R_740 | A/T | Exon 1 | 0.348 | – | – | – | AA (0.31) | AT (0.69) | TT (0.00) | Nonsynonymous |
