Fig. 5: Candidate sites for selection in Cytochrome C Oxidase (Complex IV).

A Amino acids at candidate site for positive selection in three subunits of Complex IV. B Individual OXPHOS Complex IV (Homodimer) with mitochondrial encoded subunits are represented in different colors (CO1 in orange, CO2 in yellow, CO3 in magenta and gray structures represent nuclear-encoded subunits) and three-dimensional representation of candidate site for selection in individual core subunits.