Fig. 7: Model for maternal and B chromosome drive.

The B chromosome expresses transcripts that modify its chromatin state by promoting acetylation through the activation of histone acetyltransferase (HAT) proteins. This chromatin modification (see boxes) enables the B chromosome to associate with the maternal chromosomes at the periphery of the metaphase plate. The altered chromatin state remains stable until the end of meiosis, ensuring that the B chromosome segregates with the maternal chromosomes and is transmitted to the functional spermatids. MG Maternal genome, PG Paternal genome, B B chromosome.