Fig. 7: Working model showing that the BTB-BACK-TAZ domain protein MdBT2 modulates malate accumulation and vacuolar pH. | Horticulture Research

Fig. 7: Working model showing that the BTB-BACK-TAZ domain protein MdBT2 modulates malate accumulation and vacuolar pH.

From: BTB-BACK-TAZ domain protein MdBT2-mediated MdMYB73 ubiquitination negatively regulates malate accumulation and vacuolar acidification in apple

Fig. 7

Left, with environmental stimuli (such as nitrate signaling), MdBT2 ubiquitinates MdCIbHLH1 and MdMYB73 for degradation, which reduces the transcription of malate-associated genes by MdMYB73, leading to lower malate accumulation and higher vacuolar pH. Right, with no environmental stimulus, MdCIbHLH1 enhances the activity of MdMYB73, promoting the transcription of malate-associated genes, thus resulting in higher malate accumulation and lower vacuolar pH

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