Fig. 7: Tissue-specific transcription factors based on WGCNA.

A Distribution of tissue-specific TF families across the 10 tissues related WGCNA modules. Only TF having a module membership higher than 0.9 was considered. B Heatmap showing the behavior of the main homeotic genes described in ref. 40 together with those additional MADS box identified by the WGCNA analysis. Data were normalized using the gene/row normalization provided by T-mev software. This approach transforms values using the mean and the standard deviation of the row of the matrix to which the value belongs, using the following formula: Z-score = [(value) – mean(row)]/[standard deviation(row)]. Colored boxes close to gene names indicate the homeotic class of appartenance (for genes that have one attributed to). Hierarchical clustering of both genes and samples grouped genes/samples showing similar behavior