Fig. 2: 3D model of the protein structure of DAB1 with variants compared to the wild type. | Human Genome Variation

Fig. 2: 3D model of the protein structure of DAB1 with variants compared to the wild type.

From: Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility

Fig. 2: 3D model of the protein structure of DAB1 with variants compared to the wild type.

The protein structure of DAB1 is composed of a phosphotyrosine-binding (PTB) domain (green dotted circles) and a disordered C-terminus. Val129 and Gly382 are the 129th and 382nd residues of DAB1, respectively. The 3D modeling of mutated proteins with I-TASSER indicated that DAB1-G382C and DAB1-V129I could each change the protein structure. α-helices are marked in red.

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