Table 2 PoPMuSiC analysis of how single-site mutations of XPD alter the protein folding free energy (DDG) and stability.
Residue position | Wild-type residue | Mutant residue | Solvent accessibility (%) | ΔΔG (kcal/mol) | Stability prediction |
|---|---|---|---|---|---|
461 | L | V | 0.83 | 1.4 | Destabilizing |
485 | L | P | 18.28 | 2.12 | Destabilizing |
541 | S | R | 15.22 | 1.5 | Destabilizing |
6161 | R | P | 4.44 | 0.39 | Destabilizing |
658 | R | C | 0.93 | 1.36 | Destabilizing |
681 | D | N | 0.00 | 1.39 | Destabilizing |
683 | R | Q | 6.48 | 0.83 | Destabilizing |
713 | G | R | 0.00 | 0.95 | Destabilizing |
717 | A | G | 0.00 | 1.63 | Destabilizing |
722 | R | W | 15.86 | 1.01 | Destabilizing |
725 | A | P | 6.62 | 1.62 | Destabilizing |
