Fig. 2 | Hypertension Research

Fig. 2

From: Association of histamine with hypertension-induced cardiac remodeling and reduction of hypertrophy with the histamine-2-receptor antagonist famotidine compared with the beta-blocker metoprolol

Fig. 2

Temporal variation in the blood pressure of SHRs and the response to treatment. a Temporal variation in systolic blood pressure of 6-, 9-, and 12-month-old SHRs compared with that of age- and sex-matched WST rats expressed as mmHg. b Temporal variation in diastolic blood pressure of 6-, 9-, and 12-month-old SHRs compared with that of age- and sex-matched WST rats expressed as mmHg. c Effect of famotidine on the systolic, diastolic, and mean blood pressures compared to the baseline blood pressure at initiation of treatment. The metoprolol-treated group served as a positive control. The data are presented as the mean ± SD. ‘M’ denotes months. Variation was analyzed by one-way ANOVA followed by the Bonferroni post hoc test. *p < 0.05 vs WST rats, #p < 0.01 vs WST rats, ‡p < 0.01 vs SHRs, $$p < 0.01 vs 6-month-old SHRs. ANOVA: Fig. 2a: p < 0.01, Fig. 2b: p < 0.01 and Fig. 2c: p = 0.01

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