Table 6 Receiver operating characteristic (ROC) curve values of predictive factors in discriminating APA from IHA and EHT with ARR greater than 20

From: Predictors of confirmatory test results for the diagnosis of primary hyperaldosteronism in hypertensive patients with an aldosterone-to-renin ratio greater than 20. The SHRIMP study

Variables

AUC (95% CI)

Sensitivity (%)

Specificity (%)

Cut-off point

PAC at screening, ng/dl

0.851 (0.735–0.966)

75.0

80.2

21.6

PRA at screening, ng/ml/h

0.674 (0.514–0.835)

50.0

77.9

0.35

ARR at screening

0.817 (0.672–0.962)

75.0

74.4

52.8

K, mg/dl

0.769 (0.619–0.918)

62.5

93.0

3.45

LVMI, g/m2

0.576 (0.355–0.798)

60.0

62.8

94.6

Urine β2-microgrolubin, μg/l

0.692 (0.532–0.853)

80.0

65.6

229.5

RI

0.594 (0.425–0.762)

69.2

44.0

0.575

PAC after saline-loading test

0.908 (0.789–1.000)

90.0

90.0

15.2

ARR 60 min after captopril-challenge test

0.832 (0.731–0.933)

80.0

71.1

29.3

ARR 90 min after captopril-challenge test

0.870 (0.791–0.948)

75.0

81.0

42.2

PRA after upright furosemide-loading test

0.842 (0.737–0.947)

80.0

73.1

0.55

  1. APA aldosterone-producing adenoma, ARR aldosterone-to-renin ratio, AUC area under the ROC curves, CI confidence interval, EHT essential hypertension, IHA idiopathic hyperaldosteronism, K serum potassium, LVMI left ventricle mass index, N/D not determined, PAC plasma aldosterone concentration, PRA plasma renin activity, RI resistive index.
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