Fig. 4

Glomerular podocyte injury in DSS rats. a Representative micrographs of desmin-stained renal sections. Original magnification, ×200. b Quantitative analysis of the desmin-positive area in the glomerulus. c mRNA expression of podocin. d mRNA expression of nephrin. The ΔΔCt value was calculated using data from the NS + vehicle group. *P < 0.05 vs. NS + vehicle. #P < 0.05, HS + vehicle vs. HS + losartan or HS + esaxerenone. †P < 0.05, HS + losartan vs. HS + esaxerenone