Fig. 5 | Hypertension Research

Fig. 5

From: Effect of a novel nonsteroidal selective mineralocorticoid receptor antagonist, esaxerenone (CS-3150), on blood pressure and renal injury in high salt-treated type 2 diabetic mice

Fig. 5

Effects of esaxerenone (EXR) and spironolactone (SPL) on renal inflammation. The number of mononuclear cells in the interstitial space of the kidney was quantified (a). Renal cortical tissue mRNA levels of transforming Growth Factor-β1 (TGF-β, b), monocyte chemoattractant protein-1 (MCP-1, c), and plasminogen activator inhibitor-1 (PAI-1, d) were determined by real-time reverse transcription-polymerase chain reaction. All mRNA data are expressed as the relative difference to the C57BL/6 + NS group, after normalization for β-actin expression. NS, normal salt diet; HS, high salt diet; C57BL/6, C57BL/6 mice; KK-Ay, KK-Ay mice. aP < 0.05 vs. KK-Ay + HS

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